Inactivation of yellow fever virus by glutaraldehyde

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Inactivation of yellow fever virus by glutaraldehyde.

The preservation of cellular ultrastructure by glutaraldehyde is well documented (D. D. Sabatini et al., J. Cell Biol. 17:19, 1963); however, we could find no report of its inactivation of the yellow fever virus in tissue. As laboratory infection of unvaccinated personnel by this virus is also well known (G. P. Berry and S. F. Kitchen, Am. J. Trop. Med. 11:365, 1931), it is important to ascerta...

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Inactivation of enterovirus by glutaraldehyde.

A study on the rate of inactivation by glutaraldehyde of coxsackievirus was conducted using different concentrations, temperatures, and pH values. It was found, that 2 percent glutaraldehyde at pH 7.4 and 25 C, as recommended for a sporicide, reduced the titer of infectious virus by 2 log10U in 1 min or less. The reduction was not negatively affected by high concentrations of organic matter (se...

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17D Yellow Fever Virus Vaccine

Dear Sir: In a recent article, Edupuganti and others reported a clinical study of co-administration of subcutaneous yellow fever (YF) 17D vaccine (YF-VAX Ò ; Sanofi Pasteur, Lyon, France) and intramuscular immune serum globulin (ISG) (amaSTAN S/D Ò ; Talecris Biotherapeutics, Research Triangle Park, NC) or saline placebo. 1 The study was designed to test whether co-administration of vaccine and...

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1. By the bites of stegomyia mosquitoes carrying neurotropic yellow fever virus, encephalitis has been produced both in white mice and in rhesus monkeys. 2. The fixed neurotropic strain of virus cannot be maintained in the mosquito host as well as can the viscerotropic strains. This is doubtless attributable in part to a smaller amount of virus ingested, because of paucity in the blood stream o...

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The Preservation of Yellow Fever Virus

1. The virus of yellow fever may be preserved for at least 154 days in the blood or liver tissue of infected monkeys if the material is dried in a vacuum while in the frozen state and kept in the refrigator in sealed glass containers. A gradual diminution of virulence is noticeable in the older specimens. 2. If infectious blood is dried in a vacuum at room temperature, instead of in the frozen ...

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ژورنال

عنوان ژورنال: Applied Microbiology

سال: 1968

ISSN: 0003-6919

DOI: 10.1128/am.16.1.177-.1968